Gentisuric acid

Gentisuric acid, a metabolite of Aspirin (HY-14654), is a substrate of α-amidating monooxygenase (PAM) . Gentisuric acid prevents DNA-damage by Mitomycin C (HY-13316) [1][2].

Product Specifications

CAS Number

[25351-24-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H318, H335

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gentisuric-acid.html

Purity

99.65

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

OC1=CC(C(NCC(O)=O)=O)=C(O)C=C1

Molecular Formula

C9H9NO5

Molecular Weight

211.17

Precautions

H302, H315, H318, H335

References & Citations

[1]DeBlassio JL, et al. Amidation of salicyluric acid and gentisuric acid: a possible role for peptidylglycine alpha-amidating monooxygenase in the metabolism of aspirin. Arch Biochem Biophys. 2000 Nov 1;383 (1) :46-55.|[2]Niikawa M, et al. Suppressive effect of post- or pre-treatment of aspirin metabolite on mitomycin C-induced genotoxicity using the somatic mutation and recombination test in Drosophila melanogaster. Biomed Pharmacother. 2007 Feb-Apr;61 (2-3) :113-9.