PROTAC CDK9 Degrader-1
PROTAC CDK9 Degrader-1 is a PROTAC connected by ligands for Cereblon and CDK as a selective CDK9 degrader.
Product Specifications
CAS Number
[2118356-96-8]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
CDK; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PROTAC_6.html
Purity
99.55
Solubility
DMSO : ≥ 104 mg/mL
Smiles
O=C(CC1=CC=C(OCCCCCOC2=CC=CC(C(N3C4C(NC(CC4)=O)=O)=O)=C2C3=O)C=C1)NC5=CC(C6CCC6)=NN5
Molecular Formula
C33H35N5O7
Molecular Weight
613.66
Precautions
H315, H319, H320
References & Citations
[1]Robb CM, et al. Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC) . Chem Commun (Camb) . 2017 Jul 4;53 (54) :7577-7580.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK9
Available Sizes
Curated Selection
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