KI-7

KI-7 is an A2B adenosine receptor positive allosteric modulator. KI-7 potentiates the cAMP accumulation induced by the non-selective A2B adenosine receptor agonist NECA (EC50=445.8 nM) . KI-7 also potentiates the cAMP accumulation induced by the selective A2B adenosine receptor agonist BAY 60-6583 as well as by adenosine with EC50s of 2390 nM and 2550 nM, respectively[1][2].

Product Specifications

CAS Number

[1489263-00-4]

UNSPSC

12352005

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ki-7.html

Purity

99.16

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=CC=C1)C(C2=CN(CC3=CC=CC=C3)C4=C2C=CC=C4)=O

Molecular Formula

C23H18N2O2

Molecular Weight

354.40

References & Citations

[1]Trincavelli ML, et al. Allosteric modulators of human A2B adenosine receptor. Biochim Biophys Acta. 2014;1840 (3) :1194-1203.|[2]Trincavelli ML, et al. Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators. Biochim Biophys Acta. 2014;1843 (12) :2957-2966.