EGFR WT/T790M-IN-2
EGFR WT/T790M-IN-2 (Compound 7c) is a EGFR T790M/WT inhibitor with IC50 values of 0.08 and 0.13 μM, respectively. EGFR WT/T790M-IN-2 induces apoptosis by blocking the G0-G1 phase (apoptosis) . EGFR WT/T790M-IN-2 has antitumor activity[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; EGFR
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-wt-t790m-in-2.html
Solubility
10 mM in DMSO
Smiles
N#CC1=C(N=C(N=C1C2=CC=C(F)C=C2)SC)N/N=C/C3=CC(Cl)=CC=C3
Molecular Formula
C19H13ClFN5S
Molecular Weight
397.86
References & Citations
[1]Reda N, et al. Novel Pyrimidine-5-Carbonitriles as potential apoptotic and antiproliferative agents by dual inhibition of EGFRWT/T790M and PI3k enzymes; Design, Synthesis, biological Evaluation, and docking studies. Bioorg Chem. 2024 Feb 9;145:107185.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1
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