Recombinant JAK2 (532-1132) Protein

<strong>Recombinant JAK2 (532-1132) Protein</strong>_x000D_ <strong>Catalog number:</strong> B2017629_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 10 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 71 kDa_x000D_ <strong>Supplied as:</strong> SOLUTION_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> Janus Kinase 2, Tyrosine-Protein Kinase JAK2, EC 2.7.10, JTK10_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Ungureanu D, Wu J, Pekkala T, Niranjan Y, Young C, Jensen ON, Xu CF, Neubert TA, Skoda RC, Hubbard SR, Silvennoinen O. The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling Nat Struct Mol Biol. 2011 Aug 14;18(9):971-6._x000D_ 2: Metzgeroth G, Steiner L, Naumann N, Lübke J, Kreil S, Fabarius A, Haferlach C, Haferlach T, Hofmann WK, Cross NCP, Schwaab J, Reiter A. Myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions: reevaluation of the defining characteristics in a registry-based cohort Leukemia. 2023 Sep;37(9):1860-1867._x000D_ 3: Nguyen MH, Ho JM, Beattie BK, Barber DL. TEL-JAK2 mediates constitutive activation of the phosphatidylinositol 3'-kinase/protein kinase B signaling pathway J Biol Chem. 2001 Aug 31;276(35):32704-13._x000D_ 4: Helman D, Sandowski Y, Cohen Y, Matsumoto A, Yoshimura A, Merchav S, Gertler A. Cytokine-inducible SH2 protein (CIS3) and JAK2 binding protein (JAB) abolish prolactin receptor-mediated STAT5 signaling FEBS Lett. 1998 Dec 18;441(2):287-91._x000D_ 5: Stofega MR, Argetsinger LS, Wang H, Ullrich A, Carter-Su C. Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha J Biol Chem. 2000 Sep 8;275(36):28222-9._x000D_ 6: Postel-Vinay MC, Finidori J. Growth hormone receptor: structure and signal transduction Eur J Endocrinol. 1995 Dec;133(6):654-9._x000D_ 7: Kovanen PE, Junttila I, Takaluoma K, Saharinen P, Valmu L, Li W, Silvennoinen O. Regulation of Jak2 tyrosine kinase by protein kinase C during macrophage differentiation of IL-3-dependent myeloid progenitor cells Blood. 2000 Mar 1;95(5):1626-32._x000D_ 8: Yoshimitsu M, Hachiman M, Uchida Y, Arima N, Arai A, Kamada Y, Shide K, Ito M, Shimoda K, Ishitsuka K. Essential thrombocytosis attributed to JAK2-T875N germline mutation Int J Hematol. 2019 Nov;110(5):584-590._x000D_ 9: Rauprich P, Kasper B, Tidow N, Welte K. The protein tyrosine kinase JAK2 is activated in neutrophils from patients with severe congenital neutropenia Blood. 1995 Dec 15;86(12):4500-5._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/30343638">10: Miyamoto A, Masuhiro Y, Seki T, Hanazawa S, Shiba H. A designed cell-penetrating human SOCS2 protein suppresses GH-dependent cancer cell proliferation Biosci Biotechnol Biochem. 2019 Feb;83(2):300-308. </a>_x000D_ _x000D_ <strong>Products Related to Recombinant JAK2 (532-1132) Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>