SOS1 Ligand intermediate-1
SOS1 Ligand intermediate-1 (compound 79) is a pharmaceutical intermediate that can be used to synthesize (4S) -PROTAC SOS1 degrader-1.[1].
Product Specifications
CAS Number
2245237-61-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Intermediate
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sos1-agonist-1.html
Concentration
10mM
Purity
98.94
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N1CC2(CN(C2)C3=NC4=C(N3CC5=CC(C)=C(F)C(C)=C5)C=C(Cl)C=C4Br)C1)OC(C)(C)C
Molecular Formula
C26H29BrClFN4O2
Molecular Weight
563.89
Precautions
H302, H315, H319, H335
References & Citations
[1]Hodges TR, Abbott JR, Little AJ, Sarkar D, Salovich JM, Howes JE, Akan DT, Sai J, Arnold AL, Browning C, Burns MC, Sobolik T, Sun Q, Beesetty Y, Coker JA, Scharn D, Stadtmueller H, Rossanese OW, Phan J, Waterson AG, McConnell DB, Fesik SW. Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. J Med Chem. 2018 Oct 11;61 (19) :8875-8894.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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