SOS1 Ligand intermediate-1

SOS1 Ligand intermediate-1 (compound 79) is a pharmaceutical intermediate that can be used to synthesize (4S) -PROTAC SOS1 degrader-1 (HY-144657) .[1].

Product Specifications

CAS Number

[2245237-61-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Intermediate

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sos1-agonist-1.html

Concentration

10mM

Purity

98.94

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N1CC2(CN(C2)C3=NC4=C(N3CC5=CC(C)=C(F)C(C)=C5)C=C(Cl)C=C4Br)C1)OC(C)(C)C

Molecular Formula

C26H29BrClFN4O2

Molecular Weight

563.89

Precautions

H302, H315, H319, H335

References & Citations

[1]Hodges TR, Abbott JR, Little AJ, Sarkar D, Salovich JM, Howes JE, Akan DT, Sai J, Arnold AL, Browning C, Burns MC, Sobolik T, Sun Q, Beesetty Y, Coker JA, Scharn D, Stadtmueller H, Rossanese OW, Phan J, Waterson AG, McConnell DB, Fesik SW. Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. J Med Chem. 2018 Oct 11;61 (19) :8875-8894.