GARP&Latent TGF Beta-1 Complex, Human (HEK293, His, Strep)

LRRC32 is a key regulator of TGF-β activation and maintains TGFB1, TGFB2, and TGFB3 in the latent state during extracellular storage by binding to latency-associated peptide (LAP). LRRC32 competes with LTBP1 for LAP binding and effectively regulates integrin-dependent TGF-β activation. GARP&Latent TGF Beta-1 Complex Protein, Human (HEK293, His, Strep) is a recombinant protein dimer complex containing human-derived GARP&Latent TGF Beta-1 Complex protein, expressed by HEK293 , with N-6*His, C-3*Strep labeled tag. GARP&Latent TGF Beta-1 Complex Protein, Human (HEK293, His, Strep), has molecular weight of 10-14 & 35-50 & 85-95 kDa, respectively.

LSTCKTIDME LVKRKRIEAI RGQILSKLRL ASPPSQGEVP PGPLPEAVLA LYNSTRDRVA GESAEPEPEP EADYYAKEVT RVLMVETHNE IYDKFKQSTH SIYMFFNTSE LREAVPEPVL LSRAELRLLR LKLKVEQHVE LYQKYSNNSW RYLSNRLLAP SDSPEWLSFD VTGVVRQWLS RGGEIEGFRL SAHCSCDSRD NTLQVDINGF TTGRRGDLAT IHGMNRPFLL LMATPLERAQ HLQSSRHRRA LDTNYCFSST EKNCCVRQLY IDFRKDLGWK WIHEPKGYHA NFCLGPCPYI WSLDTQYSKV LALYNQHNPG ASAAPCCVPQ ALEPLPIVYY VGRKPKVEQL SNMIVRSCKC S & HQDKVPCKMV DKKVSCQVLG LLQVPSVLPP DTETLDLSGN QLRSILASPL GFYTALRHLD LSTNEISFLQ PGAFQALTHL EHLSLAHNRL AMATALSAGG LGPLPRVTSL DLSGNSLYSG LLERLLGEAP SLHTLSLAEN SLTRLTRHTF RDMPALEQLD LHSNVLMDIE DGAFEGLPRL THLNLSRNSL TCISDFSLQQ LRVLDLSCNS IEAFQTASQP QAEFQLTWLD LRENKLLHFP DLAALPRLIY LNLSNNLIRL PTGPPQDSKG IHAPSEGWSA LPLSAPSGNA SGRPLSQLLN LDLSYNEIEL IPDSFLEHLT SLCFLNLSRN CLRTFEARRL GSLPCLMLLD LSHNALETLE LGARALGSLR TLLLQGNALR DLPPYTFANL ASLQRLNLQG NRVSPCGGPD EPGPSGCVAF SGITSLRSLS LVDNEIELLR AGAFLHTPLT ELDLSSNPGL EVATGALGGL EASLEVLALQ GNGLMVLQVD LPCFICLKRL NLAENRLSHL PAWTQAVSLE VLDLRNNSFS LLPGSAMGGL ETSLRRLYLQ GNPLSCCGNG WLAAQLHQGR VDVDATQDLI CRFSSQEEVS LSHVRPEDCE KGGLKNIN