25-Hydroxycholesterol
25-Hydroxycholesterol (25-OHC) is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.
Product Specifications
CAS Number
2140-46-7
Product Name Alternative
25-OHC
UNSPSC
12352211
Hazard Statement
H302, H312, H315, H319, H332, H335, H373
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/25-Hydroxycholesterol.html
Purity
99.98
Solubility
DMSO : 5 mg/mL (ultrasonic) |Ethanol : 14.29 mg/mL (ultrasonic)
Smiles
CC(C)(O)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Molecular Formula
C27H46O2
Molecular Weight
402.65
Precautions
H302, H312, H315, H319, H332, H335, H373
References & Citations
[1]McDonald JG, et al. Editorial: 25-Hydroxycholesterol: a new life in immunology. J Leukoc Biol. 2010 Dec;88 (6) :1071-2.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite
Available Sizes
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