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BMSpep-57 (hydrochloride)

BMSpep-57 hydrochloride is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 hydrochloride binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 hydrochloride facilitates T cell function by in creasing IL-2 production in PBMCs[1].

Product Specifications

UNSPSC

12352209

Target

PD-1/PD-L1

Type

Peptides

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bmspep-57-hydrochloride.html

Purity

99.69

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(N([C@H](C(N([C@H](C(N[C@H](C(N[C@@H](CSCC(N[C@H](C(N([C@H](C(N[C@H](C(N1[C@](CCC1)([H])C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2)=O)CO)=O)CC3=CNC4=CC=CC=C34)=O)CO)=O)CC(C)C)=O)CC5=CN=CN5)=O)=O)CC(N)=O)=O)C)C)=O)CC6=CC=CC=C6)=O)C(NCC(N)=O)=O)=O)CCCNC(N)=N)=O)CCCC)C)=O)CCCC)C)[C@@H]2CC7=CNC8=CC=CC=C78.[H]Cl

Molecular Formula

C89H127ClN24O19S

Molecular Weight

1904.63

References & Citations

[1]Aravindhan Ganesan, et al. Comprehensive in vitro characterization of PD-L1 small molecule inhibitors.Sci Rep . 2019 Aug 27;9 (1) :12392.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-P3143A/BMSpep-57-hydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-P3143A/BMSpep-57-hydrochloride-SDS-MedChemExpress.pdf

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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