UNC 669
UNC 669, a ligand for a methyl-lysine binding domain, is a potent L3MBTL1 (IC50=4.2 uM) and L3MBTL3 (3.1 uM) inhibitor[1].
Product Specifications
CAS Number
1314241-44-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/unc-669.html
Purity
99.74
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(Br)=CN=C1)N2CCC(N3CCCC3)CC2
Molecular Formula
C15H20BrN3O
Molecular Weight
338.24
Precautions
H302, H315, H319, H335
References & Citations
[1]James LI, et al. Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3. J Med Chem. 2013 Sep 26;56 (18) :7358-71.|[2]Trojer P, et al. L3MBTL1, a histone-methylation-dependent chromatin lock. Cell. 2007;129 (5) :915-928.|[3]Baughman BM, et al. The L3MBTL3 Methyl-Lysine Reader Domain Functions As a Dimer [retracted in: ACS Chem Biol. 2018 Jan 19;13 (1) :281]. ACS Chem Biol. 2016;11 (3) :722-728.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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