Abacavir (sulfate)

Abacavir sulfate (Abacavir Hemisulfate) is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir sulfate can inhibits the replication of HIV. Abacavir sulfate shows anticancer activity in prostate cancer cell lines. Abacavir sulfate can trespass the blood-brain-barrier and suppresses telomerase activity[1][2][3].

Product Specifications

CAS Number

[188062-50-2]

Product Name Alternative

Abacavir Hemisulfate; ABC sulfate

UNSPSC

12352005

Hazard Statement

H317, H319, H341

Target

Apoptosis; HIV; Reverse Transcriptase; Telomerase

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/Abacavir-sulfate.html

Purity

99.93

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic)

Smiles

O=S(O)(O)=O.NC1=NC(NC2CC2)=C3N=CN([C@H]4C=C[C@@H](CO)C4)C3=N1.[1/2]

Molecular Formula

C14H18N6O.1/2H2O4S

Molecular Weight

335.38

Precautions

H317, H319, H341

References & Citations

[1]Carlini F, et al. The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines. PLoS One. 2010 Dec 3;5 (12) :e14221.|[2]Collado-Diaz V, et al. Abacavir Induces Arterial Thrombosis in a Murine Model. J Infect Dis. 2018 Jun 20;218 (2) :228-233. |[3]Gringmuth M, et al. Enhanced Survival of High-Risk Medulloblastoma-Bearing Mice after Multimodal Treatment with Radiotherapy, Decitabine, and Abacavir. Int J Mol Sci. 2022 Mar 30;23 (7) :3815. |[4]McComsey GA, et al. Improvements in lipoatrophy, mitochondrial DNA levels and fat apoptosis after replacing stavudine with abacavir or zidovudine. AIDS. 2005 Jan 3;19 (1) :15-23.