ALK5-IN-84
ALK5-IN-84 (Compound 23) is an ALK5 inhibitor with a pKi value of 9.35 against hALK5. When administered via inhalation, ALK5-IN-84 exhibits significant ALK5 inhibitory activity. ALK5-IN-84 is promising for the development of inhaled ALK5 inhibitors[1].
Product Specifications
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK)
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/alk5-in-84.html
Smiles
O=C(NC1=NC=CC(NC2=CC(C3=CC(Cl)=CC=C3F)=NN=C2)=C1)CCN(C)C
Molecular Formula
C20H20ClFN6O
Molecular Weight
414.86
References & Citations
[1]Pala D, et al. Design, Synthesis, and Activity of a Novel Series of Pyridazine-Based ALK5 Inhibitors. ACS Med Chem Lett. 2024 Oct 23;15 (11) :1925-1932.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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