V1a/V2 antagonist 1
V1a/V2 antagonist 1 (Compound 18j) is an orally active dual V1a and V2 receptor antagonist with high binding affinity for both receptors (Ki: 0.13 nM for hV1a, 0.53 nM for hV2 and 0.5 nM for mV1a; IC50: 2.2 nM for hV1a). V1a/V2 antagonist 1 inhibits Oxytocin -induced scratching behavior in mice[1].
Product Specifications
UNSPSC
12352101
Target
Vasopressin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/v1a-v2-antagonist-1.html
Smiles
ClC1=CC=C2N3C(N(CC4)CCN4C5=C(OCC6)C6=CC=C5)=NN=C3CC7(OCCO7)CC2=C1
Molecular Formula
C25H26ClN5O3
Molecular Weight
479.96
References & Citations
[1]Varró G, et al. Development of dual V1a/V2 antagonists containing triazolobenzazepine scaffold. Eur J Med Chem. 2024 Nov 28;283:117069.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
V1a Receptor ; V2 Receptor
Frequently Asked Questions
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