Sematilide (hydrochloride)

Sematilide hydrochloride (CK-1752 hydrochloride) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM) . Sematilide is a class III antiarrhythmic agent[1].

Product Specifications

CAS Number

[101526-62-9]

Product Name Alternative

CK-1752 (hydrochloride)

UNSPSC

12352005

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/sematilide-hydrochloride.html

Purity

99.33

Solubility

DMSO : 1.67 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NCCN(CC)CC)C1=CC=C(NS(=O)(C)=O)C=C1.Cl

Molecular Formula

C14H24ClN3O3S

Molecular Weight

349.88

References & Citations

[1]Ishii Y, et al. Effects of Sematilide, a novel class III antiarrhythmic agent, on membrane currents in rabbit atrial myocytes. Eur J Pharmacol. 1997 Jul 23;331 (2-3) :295-302.|[2]Stanley S. Greenberg, et al. Pharmacology of Sematilide, a non-quaternary class III antiarrhythmic agent.