Sematilide (hydrochloride)
Sematilide hydrochloride (CK-1752 hydrochloride) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM) . Sematilide is a class III antiarrhythmic agent[1].
Product Specifications
CAS Number
[101526-62-9]
Product Name Alternative
CK-1752 (hydrochloride)
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sematilide-hydrochloride.html
Purity
99.33
Solubility
DMSO : 1.67 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NCCN(CC)CC)C1=CC=C(NS(=O)(C)=O)C=C1.Cl
Molecular Formula
C14H24ClN3O3S
Molecular Weight
349.88
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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