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PDZ1 Domain inhibitor peptide

PDZ1 Domain inhibitor peptide, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95) . PDZ1 Domain inhibitor peptide disrupts the GluR6/PSD-95 interaction and is very efficient in competing against the C terminus of GluR6 for the PDZ1 domain[1].

Product Specifications

CAS Number

[1315378-73-4]

UNSPSC

12352209

Target

IGluR

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pdz1-domain-inhibitor-peptide.html

Purity

99.04

Solubility

H2O

Smiles

O=C([C@H](CCCCN)NC([C@@H](N)CC1=CC=C(O)C=C1)=O)N[C@@H]2C(N[C@@](C(N[C@@H](CCC(NCCCC2)=O)C(N[C@@H](C)C(N[C@H](C(O)=O)C(C)C)=O)=O)=O)([H])[C@H](O)C)=O

Molecular Formula

C38H61N9O11

Molecular Weight

819.94

References & Citations

[1]Andrea Piserchio, et al. Targeting specific PDZ domains of PSD-95; structural basis for enhanced affinity and enzymatic stability of a cyclic peptide. Chem Biol. 2004 Apr;11 (4) :469-73.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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