D-GsMTx4 (TFA)

D-GsMTx4 TFA is a spider peptide and the D enantiomer of GsMTx4. D-GsMTx4 TFA inhibits the mechanosensitive ion channel Piezo2. D-GsMTx4 TFA inhibits [Ca2+]i elevation. D-GsMTx4 TFA inhibits mTOR and PI3K-Akt signaling pathways. D-GsMTx4 TFA inhibits mechanical allodynia and thermal hyperalgesia. D-GsMTx4 TFA can be used in researches of mechanical stress, chronic pain and idiopathic pulmonary fibrosis[1][2][3][4].

Product Specifications

UNSPSC

12352209

Target

Akt; Calcium Channel; mTOR; PI3K; Piezo Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/d-gsmtx4-tfa.html

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CSSC[C@@H](C(N[C@H](CCCNC(N)=N)C(N1[C@H](CCC1)C(N[C@H](CCCCN)C(N[C@H](CC(C)C)C(N[C@@H]2CCCCN)=O)=O)=O)=O)=O)NC3=O)C(N[C@H](CC(C)C)C(N[C@H](CCC(O)=O)C(N[C@H](CC4=CC=CC=C4)C(N[C@H](CC5=CNC6=CC=CC=C56)C(N[C@H](CC7=CNC8=CC=CC=C78)C(N[C@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@H](CO)C(N[C@H](CCCCN)C(N[C@H](CC(C)C)C(N[C@H](CC9=CC=CC=C9)C(N[C@H](CCCCN)C(N[C@@H]%10CC(C)C)=O)=O)=O)=O)=O)=O)NC2=O)C(N[C@H](CC(N)=O)C(N%11[C@H](CCC%11)C(N[C@H](CC(N)=O)C(N[C@H](CC(O)=O)C(N[C@H](CC(O)=O)C(N[C@H](CCCCN)C(N[C@H]3CSSC[C@@H](C(N[C@H](CC(N)=O)C(N[C@H](CC%12=CC=CC=C%12)C(N[C@H](CO)C(N[C@H](CC%13=CC=CC=C%13)C(N)=O)=O)=O)=O)=O)NC%10=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN.OC(C(F)(F)F)=O

Molecular Formula

C185H273N49O45S6.xC2HF3O2

Molecular Weight

4095.84 (free base)

References & Citations

[1]Alcaino C, et al. Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4. Channels (Austin) . 2017 May 4;11 (3) :245-253. doi: 10.1080/19336950.2017.1279370. Epub 2017 Jan 13. Erratum for: Addendum to: Wang F, Knutson K, Alcaino C, Linden DR, Gibbons SJ, Kashyap PK, Grover M, Oeckler R, Gottlieb PA, Li HJ, et al. Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces. J Physiol. 2017; 595 (1) :79-91.|[2]Eddy V A, et al. PIEZO2 Signal Transduction Mechanism and Potential Therapeutic Strategies for Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine, 2025, 211 (Abstracts) : A4722-A4722.|[3]Liu L, et al. Piezo2 Channel Upregulation is Involved in Mechanical Allodynia in CYP-Induced Cystitis Rats. Mol Neurobiol. 2023 Sep;60 (9) :5000-5012.|[4]Jo MJ, et al. Blockade of Piezo2 Pathway Attenuates Inflammatory and Neuropathic Pain in the Orofacial Area. Pain Res Manag. 2024 Sep 27;2024:9179928.