CDD-2807
CDD-2807 is an inhibitor for serine/threonine kinase 33 (STK33) with IC50 of 9.2 nM. CDD-2807 exhibits no significant toxicity in mice and can cross the blood-testis barrier without accumulating in the brain. CDD-2807 induces a reversible contraceptive effect and has potential for the development of the male contraceptive[1].
Product Specifications
CAS Number
[3086536-23-1]
UNSPSC
12352005
Target
CDK; RET; STK33
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/cdd-2807.html
Purity
99.52
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=CC2=C(NN=C2C#CC3=CC=CC=C3C4=CC=CC=C4)C=C1)N5CC6(CNCCC6)C5
Molecular Formula
C29H26N4O
Molecular Weight
446.54
References & Citations
[1]Ku AF, et al., Reversible male contraception by targeted inhibition of serine/threonine kinase 33. Science. 2024 May 24;384 (6698) :885-890.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CLK
Available Sizes
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