Demethoxycurcumin-d7
Demethoxycurcumin-d7 is the deuterium labeled Demethoxycurcumin. Demethoxycurcumin (Curcumin II), a major active curcuminoid, possess anti-inflammatory properties; also exert cytotoxic effects in human cancer cells via induction of apoptosis.
Product Specifications
CAS Number
2470243-19-5
Product Name Alternative
Curcumin II-d7; Desmethoxycurcumin-d7; Monodemethoxycurcumin-d7
UNSPSC
12352005
Target
Apoptosis; Autophagy; Bacterial; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; Autophagy; Others
Field of Research
Inflammation/Immunology; Cancer
Solubility
10 mM in DMSO
Smiles
OC(C([2H])=C1[2H])=C([2H])C([2H])=C1/C=C/C(CC(/C=C/C2=CC(OC([2H])([2H])[2H])=C(C=C2)O)=O)=O
Molecular Formula
C20H11D7O5
Molecular Weight
345.40
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Somchit M, et al. Demethoxycurcumin from Curcuma longa rhizome suppresses iNOS induction in an in vitro inflamed human intestinal mucosa model. Asian Pac J Cancer Prev. 2014;15 (4) :1807-10.|[3]Wang X, et al. Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer's disease Drosophila models. BMC Complement Altern Med. 2014 Mar 5;14:88.|[4]Ko YC, et al. Demethoxycurcumin Alters Gene Expression Associated with DNA Damage, Cell Cycle and Apoptosis in Human Lung Cancer NCI-H460 Cells In Vitro. In Vivo. 2015 01-02;29 (1) :83-94.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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