Angoline (hydrochloride)

Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1].

Product Specifications

CAS Number

[1071676-04-4]

UNSPSC

12352005

Hazard Statement

H301, H315

Target

STAT

Type

Natural Products

Related Pathways

JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/angoline-hydrochloride.html

Purity

99.53

Solubility

10 mM in DMSO

Smiles

CN1C2=C3C(C=C4OCOC4=C3)=CC=C2C5=C(C(OC)=C(OC)C=C5)C1OC.[H]Cl

Molecular Formula

C22H22ClNO5

Molecular Weight

415.87

Precautions

H301, H315

References & Citations

[1]Jiawei Liu, et al. Angoline: a selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum. Phytomedicine. Jul-Aug 2014;21 (8-9) :1088-91.