CRBN ligand-11

CRBN ligand-11 is the E3 ubiquitin ligase ligand for CFT8634 (HY-145925B) . CRBN ligand-11 can be used for the synthesis of PROTACs[1][2].

Product Specifications

CAS Number

[2962967-27-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/crbn-ligand-11.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C(NC1=CC=C(Br)C(F)=C1)CC2)NC2=O

Molecular Formula

C11H10BrFN2O2

Molecular Weight

301.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhang xue, et al. Nitrogen-containing heteroaromatic ring compound as well as composition and pharmaceutical use thereof. Patent, WO2023143370, 2023-08-03.|[2]Nasveschuk CG, et, al. Compounds for targeted degradation of brd9. Patent, WO2021178920A1, 2021-09-10.