CRBN ligand-11
CRBN ligand-11 is the E3 ubiquitin ligase ligand for CFT8634 (HY-145925B) . CRBN ligand-11 can be used for the synthesis of PROTACs[1][2].
Product Specifications
CAS Number
[2962967-27-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/crbn-ligand-11.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C(NC1=CC=C(Br)C(F)=C1)CC2)NC2=O
Molecular Formula
C11H10BrFN2O2
Molecular Weight
301.11
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang xue, et al. Nitrogen-containing heteroaromatic ring compound as well as composition and pharmaceutical use thereof. Patent, WO2023143370, 2023-08-03.|[2]Nasveschuk CG, et, al. Compounds for targeted degradation of brd9. Patent, WO2021178920A1, 2021-09-10.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
Curated Selection
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