PD-134672
PD-134672 (CI-992) is a renin inhibitor containing a 2-amino-4-thiazolyl substituent. PD-134672 potently inhibits monkey renin in vitro and only weakly inhibits the related aspartic protease bovine feline hepsin D. The compound exhibits oral hypotensive activity in hyperreninemic normotensive monkeys. Based on its superior efficacy and long-lasting effects in vitro and in the normotensive macaque model, PD-134672 was selected for further evaluation in renal hypertensive monkeys.
Product Specifications
CAS Number
135704-06-2
Product Name Alternative
CI-992
UNSPSC
12352005
Target
Renin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pd-134672.html
Smiles
O=S(N[C@H](C(N[C@H](C(N[C@@]([C@@H](O)[C@@H](O)CC(C)C)([H])CC1CCCCC1)=O)CC2=CSC(N)=N2)=O)CC3=CC=CC=C3)(N4CCOCC4)=O
Molecular Formula
C33H52N6O7S2
Molecular Weight
708.93
References & Citations
[1]Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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