CCG-4986

CCG-4986 is an RGS protein inhibitor. CCG-4986 inhibits protein activity by covalently modifying the Cys-132 site of RGS4. CCG-4986 can be used to study diseases related to dysregulated G protein-coupled receptor (GPCR) signaling, such as Parkinson's disease and opioid addiction[1].

Product Specifications

CAS Number

[7134-19-2]

UNSPSC

12352005

Hazard Statement

H319

Target

RGS Protein

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Others

Assay Protocol

https://www.medchemexpress.com/ccg-4986.html

Smiles

O=[N+](C1=CC=C(/S(OC)=N\S(=O)(C2=CC=C(Cl)C=C2)=O)C=C1)[O-]

Molecular Formula

C13H11ClN2O5S2

Molecular Weight

374.82

Precautions

P264-P280-P305+P351+P338

References & Citations

[1]Kimple AJ, et al. The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction face. Biochim Biophys Acta. 2007 Sep;1774 (9) :1213-20.