OVCA2 Protein, Human Recombinant

Ovarian tumor suppressor candidate 2, also known as OVCA2, belongs to the uPF0483 family. It is ubiquitously expressed and produces proteins that help repair damaged DNA and slows cell division. Its expression is regulated by retinoids. OVCA2 interacts with apoptosis-related protein Bag-1, indicating that this protein may participate in cell proliferation. Due to its structural and catalytic characteristics, OVCA2 is thought to act as a serine-hydrolase and, because of its reduced expression in ovarian and other tumor cell lines; it may play a role in tumor suppression. Recombinant human OVCA2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.