UDP-GalNAc (disodium)

UDP-GalNAc (UDP-N-acetyl-D-galactosamine) disodium is a sugar nucleotide and a substrate for EpsC115. EpsC115 is a mutant with N-terminal residues 1-115 deleted from the exopolymeric substance (EPS) . UDP-GalNAc disodium is a donor substrate for many N-acetylgalactosaminyltransferases, which transfer GalNAc from nucleotide sugars to sugar or peptide acceptors. UDP-GalNAc disodium provides a sugar group donor for glycosylation reactions. UDP-GalNAc disodium can be used in cancer research, such as colorectal and breast cancer[1][2][3][4].

Product Specifications

CAS Number

[108320-87-2]

Product Name Alternative

UDP-N-acetyl-D-galactosamine (disodium)

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/udp-galnac-disodium.html

Purity

99.98

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(O[C@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3NC(C)=O)(O[Na])=O)(O[Na])=O)O2)NC1=O

Molecular Formula

C17H25N3Na2O17P2

Molecular Weight

651.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Kaundinya CR, et al. In vitro characterization of N-terminal truncated EpsC from Bacillus subtilis 168, a UDP-N-acetylglucosamine 4,6-dehydratase. Arch Biochem Biophys. 2018 Nov 1;657:78-88.|[2]Hang HC, et al. Probing glycosyltransferase activities with the Staudinger ligation. J Am Chem Soc. 2004 Jan 14;126 (1) :6-7. |[3]Song L, et al. Inhibitor of ppGalNAc-T3-mediated O-glycosylation blocks cancer cell invasiveness and lowers FGF23 levels. Elife. 2017 Mar 31;6:e24051. |[4]Kohsaki T, et al. Expression of UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase isozymes T1 and T2 in human colorectal cancer. J Gastroenterol. 2000;35 (11) :840-8.