Recombinant Human Claudin-18.2 (CLDN18.2) -Detergent (Active)

Product Specifications

CAS Number

9000-83-3

Gene Name

CLDN18.2

UniProt

P56856-2

Expression Region

1-261aa

Organism

Homo sapiens

Target Sequence

MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV

Tag

C-terminal 10xHis-tagged

Source

Mammalian cell

Field of Research

Signal Transduction

Assay Type

MP-Detergent Transmembrane Protein & Active Protein & In Stock Protein

Relevance

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Purity

Greater than 80% as determined by SDS-PAGE.

Activity

Yes

Bioactivity

Measured by its binding ability in a functional ELISA. Immobilized Human CLDN18.2 at 5 μg/mL on an Nickel Coated plate can bind Anti-CLDN18.2 recombinant antibody (CSB-RA005505MA1HU), the EC50 is 0.4640-0.6372 ng/mL.

Length

Full Length of Isoform A2

Form

Liquid

Buffer

50 mM HEPES，0.15 M NaCl， 0.05% DDM，0.01% CHS，pH7.5

Molecular Weight

29.1 kDa

References & Citations

"Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development." Sahin U., Koslowski M., Dhaene K., Usener D., Brandenburg G., Seitz G., Huber C., Tuereci O. Clin. Cancer Res. 14:7624-7634 (2008)

Storage Conditions

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.