(S) -Coriolic acid

(S) -Coriolic acid (13 (S) -HODE), the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ. (S) -Coriolic acid is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. (S) -Coriolic acid induces mitochondrial dysfunction and airway epithelial injury[1][2][3].

Product Specifications

CAS Number

[29623-28-7]

Product Name Alternative

13 (S) -HODE

UNSPSC

12352211

Hazard Statement

H225, H319

Target

Mitochondrial Metabolism; PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/s-coriolic-acid.html

Concentration

337.33 μM * 2.5 mL in Ethanol

Purity

99.0

Solubility

10 mM in DMSO

Smiles

CCCCC[C@H](O)/C=C/C=C\CCCCCCCC(O)=O

Molecular Formula

C18H32O3

Molecular Weight

296.44

Precautions

H225, H319

References & Citations

[1]Mabalirajan U, et al. Linoleic acid metabolite drives severe asthma by causing airway epithelial injury. Sci Rep. 2013;3:1349.|[2]Ogawa E, et al. Epidermal FABP (FABP5) regulates keratinocyte differentiation by 13 (S) -HODE-mediated activation of the NF-κB signaling pathway. J Invest Dermatol. 2011;131 (3) :604-612.|[3]Yuan H, et al. 15-Lipoxygenases and its metabolites 15 (S) -HETE and 13 (S) -HODE in the development of non-small cell lung cancer. Thorax. 2010;65 (4) :321-326.