Xanthoangelol

Xanthoangelol, extracted from Angelica keiskei, suppresses obesity-induced inflammatory responses. Xanthoangelol possesses antibacterial activity. Xanthoangelol inhibits monoamine oxidases. Xanthoangelol induces apoptosis in neuroblastoma and leukemia cells[1][2][3][4].

Product Specifications

CAS Number

[62949-76-2]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

AMPK; Apoptosis; Bacterial; Caspase; Monoamine Oxidase

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Epigenetics; Neuronal Signaling; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/xanthoangelol.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(/C=C/C1=CC=C(O)C=C1)C2=CC=C(O)C(C/C=C(C)/CC/C=C(C)/C)=C2O

Molecular Formula

C25H28O4

Molecular Weight

392.49

Precautions

H302, H312, H332

References & Citations

[1]Li Y, et al. Xanthoangelol and 4-hydroxyderrcin suppress obesity-induced inflammatory responses. Obesity (Silver Spring) . 2016 Nov;24 (11) :2351-2360.|[2]Inamori Y, et al. Antibacterial activity of two chalcones, xanthoangelol and 4-hydroxyderricin, isolated from the root of Angelica keiskei KOIDZUMI. Chem Pharm Bull (Tokyo) . 1991 Jun;39 (6) :1604-5.|[3]Kim JH, et al. Xanthoangelol and 4-Hydroxyderricin Are the Major Active Principles of the Inhibitory Activities against Monoamine Oxidases on Angelica keiskei K. Biomol Ther (Seoul) . 2013 May 30;21 (3) :234-40.|[4]Keiichi TABATA, et al. Xanthoangelol, a Major Chalcone Constituent of Angelica keiskei, Induces Apoptosis in Neuroblastoma and Leukemia Cells. Biol. Pharm. Bull. 28 (8) 1404-1407 (2005) .