TC-G 1004
TC-G 1004 (compound 16j) is an orally active A2A adenosine receptor antagonist, with Ki values of 0.44 nM and 80 nM for hA2A and hA1, respectively[1].
Product Specifications
CAS Number
1061747-72-5
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tc-g-1004.html
Purity
98.11
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(NC1=NC(N2N=C(C)C=C2C)=NC(C3=NC(N4CCC(OC)CC4)=CC=C3)=C1)=O
Molecular Formula
C22H27N7O2
Molecular Weight
421.50
References & Citations
[1]Xiaohu Zhang, et al. Lead optimization of 4-acetylamino-2- (3,5-dimethylpyrazol-1-yl) -6-pyridylpyrimidines as A2A adenosine receptor antagonists for the treatment of Parkinson's disease. J Med Chem. 2008 Nov 27;51 (22) :7099-110.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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