TC-G 1004

TC-G 1004 (compound 16j) is an orally active A2A adenosine receptor antagonist, with Ki values of 0.44 nM and 80 nM for hA2A and hA1, respectively[1].

Product Specifications

CAS Number

[1061747-72-5]

UNSPSC

12352005

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tc-g-1004.html

Purity

98.11

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(NC1=NC(N2N=C(C)C=C2C)=NC(C3=NC(N4CCC(OC)CC4)=CC=C3)=C1)=O

Molecular Formula

C22H27N7O2

Molecular Weight

421.50

References & Citations

[1]Xiaohu Zhang, et al. Lead optimization of 4-acetylamino-2- (3,5-dimethylpyrazol-1-yl) -6-pyridylpyrimidines as A2A adenosine receptor antagonists for the treatment of Parkinson's disease. J Med Chem. 2008 Nov 27;51 (22) :7099-110.