AM-0687
AM-0687 is a selective inhibitor for PI3Kδ with an IC50 of 2.9 nM. AM-0687 decreases the levels of IgG and IgM specific antibodies, inhibits the anti-IgM/CD40L-induced proliferation of human B cell (IC50=0.8 nM) and the phosphorylation of AKT (IC50=0.7 nM), and exhibits anti-inflammatory efficacy[1].
Product Specifications
CAS Number
1259522-94-5
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/am-0687.html
Smiles
O=C(C1=C(C2=NC=CC=C2)C([C@@H](NC3=NC=NC(N)=C3C#N)C)=NC4=CC=C(F)C=C14)NC
Molecular Formula
C23H19FN8O
Molecular Weight
442.45
Precautions
P261-P280-P302+P352
References & Citations
[1]Gonzalez-Lopez de Turiso F, et al. Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2- ((1S) -1- ((6-Amino-5-cyano-4-pyrimidinyl) amino) ethyl) -6-fluoro-N-methyl-3- (2-pyridinyl) -4-quinolinecarboxamide (AM-0687) and 2- ((1S) -1- ((6-Amino-5-cyano-4-pyrimidinyl) amino) ethyl) -5-fluoro-N-methyl-3- (2-pyridinyl) -4-quinolinecarboxamide (AM-1430) . J Med Chem. 2016 Aug 11;59 (15) :7252-67.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
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