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VLX600

VLX600 is an iron-chelating inhibitor of oxidative phosphorylation (OXPHOS) . VLX600 causes mitochondrial dysfunction and induces a strong shift to glycolysis. VLX600 displays selective cytotoxic activity against malignant cell and induces autophagy. Anticancer activity[1][2].

Product Specifications

CAS Number

327031-55-0

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Autophagy; Mitochondrial Metabolism; Oxidative Phosphorylation

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vlx600.html

Purity

99.80

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CC1=C(NC2=C3N=NC(N/N=C(C4=CC=CC=N4)\C)=N2)C3=CC=C1

Molecular Formula

C17H15N7

Molecular Weight

317.35

Precautions

H315, H319, H335

References & Citations

[1]Karlsson H, et al. A novel tumor spheroid model identifies selective enhancement of radiation by an inhibitor of oxidative phosphorylation. Oncotarget. 2019 Sep 3;10 (51) :5372-5382.|[2]Zhang X, et al. Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments. Nat Commun. 2014;5:3295.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Available Sizes

Frequently Asked Questions

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