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D-Psicose-d

D-Psicose-d is the deuterium labeled D-Psicose. D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and MCP-1 expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease[1][2][3][4][5].

Product Specifications

CAS Number

53685-24-8

Product Name Alternative

D-Allulose-d

UNSPSC

12352211

Target

Isotope-Labeled Compounds; NF-κB; p38 MAPK

Type

Isotope-Labeled Compounds

Related Pathways

MAPK/ERK Pathway; NF-κB; Others

Field of Research

Metabolic Disease

Purity

99.9

Solubility

10 mM in DMSO

Smiles

OCC([C@]([C@@H]([C@@H](CO)O)O)([2H])O)=O

Molecular Formula

C6H11DO6

Molecular Weight

181.16

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Murao K, et al. D-Psicose inhibits the expression of MCP-1 induced by high-glucose stimulation in HUVECs. Life Sci. 2007 Jul 26;81 (7) :592-9.|[3]Hossain A, et al. Rare sugar D-psicose protects pancreas β-islets and thus improves insulin resistance in OLETF rats. Biochem Biophys Res Commun. 2012 Sep 7;425 (4) :717-23.|[4]Baek SH, et al. D-psicose, a sweet monosaccharide, ameliorate hyperglycemia, and dyslipidemia in C57BL/6J db/db mice. J Food Sci. 2010 Mar;75 (2) :H49-53.|[5]Tan J, et al. D-Psicose mitigates NAFLD mice induced by a high-fat diet by reducing lipid accumulation, inflammation, and oxidative stress. Front Nutr. 2025 May 27;12:1574151. |[6]Zeng Y, et al. Dietary D-psicose, a rare sugar, shows no modifying effects in a medium-term liver carcinogenesis bioassay in F344 male rats. Journal of toxicologic pathology, 2005, 18 (2) : 85-88.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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