D-Psicose-d
D-Psicose-d is the deuterium labeled D-Psicose. D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and MCP-1 expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease[1][2][3][4][5].
Product Specifications
CAS Number
53685-24-8
Product Name Alternative
D-Allulose-d
UNSPSC
12352211
Target
Isotope-Labeled Compounds; NF-κB; p38 MAPK
Type
Isotope-Labeled Compounds
Related Pathways
MAPK/ERK Pathway; NF-κB; Others
Field of Research
Metabolic Disease
Purity
99.9
Solubility
10 mM in DMSO
Smiles
OCC([C@]([C@@H]([C@@H](CO)O)O)([2H])O)=O
Molecular Formula
C6H11DO6
Molecular Weight
181.16
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Murao K, et al. D-Psicose inhibits the expression of MCP-1 induced by high-glucose stimulation in HUVECs. Life Sci. 2007 Jul 26;81 (7) :592-9.|[3]Hossain A, et al. Rare sugar D-psicose protects pancreas β-islets and thus improves insulin resistance in OLETF rats. Biochem Biophys Res Commun. 2012 Sep 7;425 (4) :717-23.|[4]Baek SH, et al. D-psicose, a sweet monosaccharide, ameliorate hyperglycemia, and dyslipidemia in C57BL/6J db/db mice. J Food Sci. 2010 Mar;75 (2) :H49-53.|[5]Tan J, et al. D-Psicose mitigates NAFLD mice induced by a high-fat diet by reducing lipid accumulation, inflammation, and oxidative stress. Front Nutr. 2025 May 27;12:1574151. |[6]Zeng Y, et al. Dietary D-psicose, a rare sugar, shows no modifying effects in a medium-term liver carcinogenesis bioassay in F344 male rats. Journal of toxicologic pathology, 2005, 18 (2) : 85-88.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
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