Pep2m, myristoylated

Pep2m, myristoylated (Myr-Pep2m) is a cell-permeable peptide. Pep2m, myristoylated can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC) [1][2].

Product Specifications

CAS Number

[1423381-07-0]

Product Name Alternative

Myr-Pep2m

UNSPSC

12352209

Target

PKC

Type

Peptides

Related Pathways

Epigenetics; TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pep2m-myristoylated.html

Solubility

10 mM in DMSO

Smiles

CCCCCCCCCCCCCC([K])=O.[R][M]([V][*](N([Q])[*])[K])[K]

Molecular Formula

C63H118N18O14S

Molecular Weight

1383.81

References & Citations

[1]Yudong Yao, et al. PKMζ Maintains Late Long-Term Potentiation by N-Ethylmaleimide-Sensitive Factor/GluR2-Dependent Trafficking of Postsynaptic AMPA Receptors. J Neurosci. 2008 Jul 30; 28 (31) : 7820-7827.|[2]Nicole C George, et al. Sex differences in the contributions of spinal atypical PKCs and downstream targets to the maintenance of nociceptive sensitization. Mol Pain. 2019; 15: 1744806919840582.