12-Ethyl-9-hydroxycamptothecin
12-Ethyl-9-hydroxycamptothecin is a derivative of Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1].
Product Specifications
CAS Number
[119577-28-5]
UNSPSC
12352005
Hazard Statement
H301
Target
Topoisomerase
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/12-ethyl-9-hydroxycamptothecin.html
Purity
99.89
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C(O)C=CC(CC)=C5N=C4C3=C2)=O
Molecular Formula
C22H20N2O5
Molecular Weight
392.40
Precautions
H301
References & Citations
[1]Luzzio MJ, et al. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I. J Med Chem. 1995;38 (3) :395-401.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
