Human Caspase-1 Protein, His Tag&Tag Free
Caspases are an evolutionary conserved family of cysteine-dependent proteases that are involved in many vital cellular processes including apoptosis, proliferation, differentiation and inflammatory response. Dysregulation of caspase-mediated apoptosis and inflammation has been linked to the pathogenesis of various diseases such as inflammatory diseases, neurological disorders, metabolic diseases, and cancer.The members of the caspase family are grouped based on their functional contribution in inflammation (caspases-1, -4, -5, and -11) and involvement in cell death (initiation: caspases-2, -8, -9, and -10; execution: caspases-3, -6, and -7) or by their consensus recognition sequences. Inflammatory caspases recognize the sequence Trp-Glu-His-Asp and are classified as group I. Whilst group II and group III recognize Asp-Glu-X-Asp and (Leu/Val) -Glu-X-Asp, respectively.
Product Specifications
Background
Specifications
Accession Number
P29466-1
Expression Region
Asn 120 - Asp 297 & Ala 317 - His 404
Host
E. coli
Target
Caspase-1
Conjugation
Unconjugated
Tag
N-10xHis | Native
Stability
The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.
Endotoxin
1.0 EU per μg
Purity
90%
Format
Liquid
Buffer
20 mM Tris, 300 mM NaCl, 0.5 M Arginine, pH8.0
Additives
Glycerol
Molecular Weight
21.9 kDa & 10.4 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
25ug*1
Host or Source
E. coli
Species
Human
Protein ID
P29466-1
Preservative
Glycerol
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