Sulfosuccinimidyl oleate (sodium)
Product Specifications
UNSPSC Description
Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect[1][2].
Target Antigen
Mitophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sulfosuccinimidyl-oleate-sodium.html
Purity
98.0
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=S(C(C1)C(N(OC(CCCCCCC/C=C\CCCCCCCC)=O)C1=O)=O)(O[Na])=O
Molecular Weight
481.58
References & Citations
[1]Dhungana H, et al. Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation. J Neuroinflammation. 2017 Dec 4;14(1):237.|[2]Drahota Z, et al. Succinimidyl oleate, established inhibitor of CD36/FAT translocase inhibits complex III of mitochondrial respiratory chain. Biochem Biophys Res Commun. 2010 Jan 15;391(3):1348-51.Cell Death Dis. 2024 Aug 26;15(8):623.|Cell Rep Med. 2024 May 29:101592.|Cell Rep. 2024 Oct 19;43(11):114881.|Heliyon. 2024 Nov 28;10(23):e40806.|J Agric Food Chem. 2024 Jul 10.|J Exp Med. 2023 Mar 6;220(3):e20221316.|J Transl Med. 2023 Feb 6;21(1):89.|Research Square Preprint. 2023 Oct 11.|Research Square Print. December 29th, 2022.|BMC Cancer. 2023 Apr 21;23(1):367.|Cancer Lett. 2023 Nov 25, 216511.|Cell Immunol. 11 January 2022, 104475.|Cell Rep. 2024 Jul 9;43(7):114465.|CNS Neurosci Ther. 2023 May 8.|Food Res Int. 2023 Nov, 173, 113328.|Food Sci Nutr. 2023 Nov 22.|Front Pharmacol. 2020 Dec 16;11:593832.|Int J Biol Macromol. 2023 Oct 12:127324.|Int J Mol Sci. 2023 Aug 31, 24(17), 13516.|SSRN. 2023 Aug 30.|Toxicol Sci. 2022 Dec 19;kfac133.|Toxins. 2021, 13(11), 802.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112847A/Sulfosuccinimidyl-oleate-sodium-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112847A/Sulfosuccinimidyl-oleate-sodium-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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