LMP7/LMP2-IN-1
LMP7/LMP2-IN-1 (Compound 19) is the orally active inhibitor for immunoproteasome subunits LMP7 and LMP2 with IC50 of 257 and 10 nM. LMP7/LMP2-IN-1 reduces the generation of antibody, downregulates the cells in spleen germinal center B and in plasma in NP-OVA-immunized mice, and can be used in research about autoimmune diseases[1].
Product Specifications
CAS Number
[3053755-09-9]
UNSPSC
12352211
Target
Proteasome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lmp7-lmp2-in-1.html
Smiles
OB(O)[C@@H](NC(C1=CN(C2CCCCC2)N=N1)=O)C3CCCCC3
Molecular Formula
C16H27BN4O3
Molecular Weight
334.22
References & Citations
[1]Arai Y, et al., Optimization of α-amido boronic acids via cryo-electron microscopy analysis: Discovery of a novel highly selective immunoproteasome subunit LMP7 (β5i) /LMP2 (β1i) dual inhibitor. Bioorg Med Chem. 2024 Jul 15;109:117790.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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