LMP7/LMP2-IN-1

LMP7/LMP2-IN-1 (Compound 19) is the orally active inhibitor for immunoproteasome subunits LMP7 and LMP2 with IC50 of 257 and 10 nM. LMP7/LMP2-IN-1 reduces the generation of antibody, downregulates the cells in spleen germinal center B and in plasma in NP-OVA-immunized mice, and can be used in research about autoimmune diseases[1].

Product Specifications

CAS Number

[3053755-09-9]

UNSPSC

12352211

Target

Proteasome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/lmp7-lmp2-in-1.html

Smiles

OB(O)[C@@H](NC(C1=CN(C2CCCCC2)N=N1)=O)C3CCCCC3

Molecular Formula

C16H27BN4O3

Molecular Weight

334.22

References & Citations

[1]Arai Y, et al., Optimization of α-amido boronic acids via cryo-electron microscopy analysis: Discovery of a novel highly selective immunoproteasome subunit LMP7 (β5i) /LMP2 (β1i) dual inhibitor. Bioorg Med Chem. 2024 Jul 15;109:117790.