ITX3

ITX3 is a specific and nontoxic inhibitor of TrioN (N-terminal GEF domain of the multidomain Trio protein) with an IC50 value of 76 μM. ITX3 can be used for the research of agent[1][2].

Product Specifications

CAS Number

[347323-96-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ITX3.html

Purity

98.60

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C(/C1=C\C2=C(C)N(C(C)=C2)C3=CC=CC=C3)N4C(S1)=NC5=CC=CC=C45

Molecular Formula

C22H17N3OS

Molecular Weight

371.45

Precautions

H302, H315, H319

References & Citations

[1]Bouquier N, et al. A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway. Chem Biol. 2009 Jun 26;16 (6) :657-66.|[2]Yano T, et al. Tara up-regulates E-cadherin transcription by binding to the Trio RhoGEF and inhibiting Rac signaling. J Cell Biol. 2011 Apr 18;193 (2) :319-32.