Nebentan (potassium)
Nebentan potassium (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan. Nebentan potassium inhibits [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with Ki of 0.697 nM and 569 nM, respectively[1]. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo[2].
Product Specifications
CAS Number
342005-82-7
Product Name Alternative
YM598
UNSPSC
12352005
Target
Endothelin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/nebentan-potassium.html
Purity
99.53
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=S(/C=C/C1=CC=CC=C1)([N-]C2=NC(C3=NC=CC=N3)=NC(OC)=C2OC4=CC=CC=C4OC)=O.[K+]
Molecular Formula
C24H20KN5O5S
Molecular Weight
529.61
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
ETA; ETB
Available Sizes
Frequently Asked Questions
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