Amprolium (hydrochloride)

Amprolium hydrochloride is an anti-parasitic drug that's kind of taken orally, and it acts as an antagonist to thiamine in intestinal absorption[1][2][3][4].

Product Specifications

CAS Number

[137-88-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Amprolium-hydrochloride.html

Purity

98.79

Solubility

H2O : ≥ 200 mg/mL

Smiles

CC1=CC=CC=[N+]1CC2=CN=C(CCC)N=C2N.[Cl-].Cl

Molecular Formula

C14H20Cl2N4

Molecular Weight

315.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Iqbal A, et al. Antiparasitic efficacy of Artemisia absinthium, toltrazuril and amprolium against intestinal coccidiosis in goats. J Parasit Dis. 2013 Apr;37 (1) :88-93.|[2]Lindsay DS, et al. Effects of sulfadiazine and amprolium on Neospora caninum (Protozoa: Apicomplexa) infections in mice. J Parasitol. 1990 Apr;76 (2) :177-9.|[3]Kennedy O Ogolla, et al. Efficacy of Sulphachloropyrazine, Amprolium Hydrochloride, Trimethoprim-Sulphamethoxazole, and Diclazuril against Experimental and Natural Rabbit Coccidiosis. J Vet Med. 2018 Oct 23:2018:5402469.|[4]G Rindi, et al. Action of Amprolium on the thiamine content of rat tissues. J Nutr. 1966 Jun;89 (2) :197-202.