RBPJ Inhibitor-1
RBPJ Inhibitor-1 (RIN1), the first RBPJ inhibitor, blocks the functional interaction of RBPJ with SHARP. RBPJ Inhibitor-1 (RIN1) inhibits NOTCH-dependent tumor cell proliferation[1].
Product Specifications
CAS Number
[2682114-39-0]
Product Name Alternative
RIN1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Notch
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rbpj-inhibitor-1.html
Concentration
10mM
Purity
99.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N)C1=CC=C(C2=CC=NN2C)C=C1OC3=CC=CC=C3F
Molecular Formula
C17H14FN3O2
Molecular Weight
311.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Cecilia Hurtado, et al. Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ. Sci Rep. 2019 Jul 25;9 (1) :10811.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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