Equilin
Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone) . Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism[1][2].
Product Specifications
CAS Number
474-86-2
Product Name Alternative
7-Dehydroestrone
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/Equilin.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 4 mg/mL (ultrasonic)
Smiles
C[C@]1([C@](CC2)([H])C3=CCC4=C(C=CC(O)=C4)[C@@]3([H])CC1)C2=O
Molecular Formula
C18H20O2
Molecular Weight
268.35
Precautions
H302, H315, H319, H335
References & Citations
[1]David K, et al. Some biological properties of equilin. Biochem J. 1935;29 (2) :371-377.|[2]Brinton RD, et al. Equilin, a principal component of the estrogen replacement therapy premarin, increases the growth of cortical neurons via an NMDA receptor-dependent mechanism. Exp Neurol. 1997;147 (2) :211-220.|[3]Ito F, et al. Equilin in conjugated equine estrogen increases monocyte-endothelial adhesion via NF-κB signaling. PLoS One. 2019;14 (1) :e0211462. Published 2019 Jan 30.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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