Equilin

Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone) . Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism[1][2].

Product Specifications

CAS Number

[474-86-2]

Product Name Alternative

7-Dehydroestrone

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/Equilin.html

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : 4 mg/mL (ultrasonic)

Smiles

C[C@]1([C@](CC2)([H])C3=CCC4=C(C=CC(O)=C4)[C@@]3([H])CC1)C2=O

Molecular Formula

C18H20O2

Molecular Weight

268.35

Precautions

H302, H315, H319, H335

References & Citations

[1]David K, et al. Some biological properties of equilin. Biochem J. 1935;29 (2) :371-377.|[2]Brinton RD, et al. Equilin, a principal component of the estrogen replacement therapy premarin, increases the growth of cortical neurons via an NMDA receptor-dependent mechanism. Exp Neurol. 1997;147 (2) :211-220.|[3]Ito F, et al. Equilin in conjugated equine estrogen increases monocyte-endothelial adhesion via NF-κB signaling. PLoS One. 2019;14 (1) :e0211462. Published 2019 Jan 30.