Perospirone-d8

Perospirone-d8 (SM-9018-d8 (free base) ) is deuterium labeled Perospirone. Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and also a partial agonist of 5-HT1A receptor (Ki=2.9 nM) . Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research[1][2][3].

Product Specifications

Product Name Alternative

SM-9018-d8 (free base)

UNSPSC

12352005

Target

5-HT Receptor; Dopamine Receptor; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

O=C([C@]1([H])[C@](CCCC1)([H])C2=O)N2C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])N3CCN(CC3)C4=NSC5=CC=CC=C45

Molecular Formula

C23H22D8N4O2S

Molecular Weight

434.62

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Kato T, et al. Binding profile of SM-9018, a novel antipsychotic candidate. pn J Pharmacol. 1990 Dec;54 (4) :478-81.|[3]Hagiwara H, et al. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: role of serotonin 5-HT1A receptors. Eur Neuropsychopharmacol. 2008 Jun;18 (6) :448-54.