[D-Phe2, D-Ala6]-LH-RH

[D-Phe2, D-Ala6]-LH-RH is a potent LH-RH antagonist. [D-Phe2, D-Ala6]-LH-RH shows anti-LH/FSH-RH and antiovulatory activities[1].

Product Specifications

CAS Number

[54784-44-0]

Product Name Alternative

Wy 18185

UNSPSC

12352209

Hazard Statement

H302-H315-H319-H335

Target

GnRH Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/d-phe2-d-ala6-lh-rh.html

Solubility

H2O

Smiles

O=C([C@H]1NC(CC1)=O)N[C@H](CC2=CC=CC=C2)C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N3[C@@H](CCC3)C(NCC(N)=O)=O)=O)=O)=O)=O)CC4=CC=C(C=C4)O)=O)=O)CC5=CNC6=CC=CC=C56)=O

Molecular Formula

C59H79N15O13

Molecular Weight

1206.35

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Vilchez-Martinez JA, et al. Comparison of the anti-LH/FSH-RH and anti-ovulatory activities of (D-Phe2, D-Leu6) -LH-RH and (D-Phe2, D-Ala6) -LH-RH. Endocr Res Commun. 1976;3 (3-4) :231-41.|[2]Beattie CW, et al. Luteinizing hormone-releasing hormone. Antiovulatory activity of analogs substituted in positions 2 and 6. J Med Chem. 1975 Dec;18 (12) :1247-50. |[3]Corbin A, et al. Effect of luteinizing hormone releasing hormone (LHRH) and an LHRH antagonist of hypothalamic and plasma LHRH of hypophysectomized rats. Endocrinology. 1976 Jan;98 (1) :247-50. |[4]Corbin A, et al. Ihibition of the pre-ovulatory proestrous gonadotropin surge, ovulation and pregnancy with a peptide analogue of luteinizing hormone releasing hormone. Endocr Res Commun. 1975;2 (1) :1-23.