Opicapone (Standard)
Opicapone (Standard) is the analytical standard of Opicapone. This product is intended for research and analytical applications. Opicapone (BIA 9-1067) is a potent third-generation catechol-O-methyltransferase (COMT) inhibitor for the research of Parkinson's disease and motor fluctuations. Opicapone decreases the ATP content of the cells with an IC50 of 98 μM[1].
Product Specifications
CAS Number
923287-50-7
Product Name Alternative
BIA 9-1067 (Standard)
UNSPSC
12352005
Target
COMT; Reference Standards
Type
Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling; Others
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/opicapone-standard.html
Smiles
CC1=[N+]([O-])C(Cl)=C(C2=NOC(C3=CC([N+]([O-])=O)=C(O)C(O)=C3)=N2)C(C)=C1Cl
Molecular Formula
C15H10Cl2N4O6
Molecular Weight
413.17
References & Citations
[1]Bonifácio MJ, et al. Pharmacological profile of Opicapone, a third-generation nitrocatechol catechol-O-methyl transferase inhibitor, in the rat. Br J Pharmacol. 2015 Apr;172 (7) :1739-52.|[2]Ferreira JJ, et al. Opicapone as an adjunct to L-DOPA in patients with Parkinson's disease and end-of-dose motor fluctuations: a randomised, double-blind, controlled trial. Lancet Neurol. 2016 Feb;15 (2) :154-165.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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